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Symbol Name ID |
Il6st
interleukin 6 signal transducer MGI:96560 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgE level |
Eosinophilia |
Recurrent otitis media |
Keratitis |
Eczematoid dermatitis |
Food allergy |
Recurrent respiratory infections |
| Disease(s) Associated with IL6ST | |||||||
| hyper IgE recurrent infection syndrome 4 |
| Mouse Phenotypes | abnormal osteoclast differentiation |
decreased susceptibility to induced colitis |
increased susceptibility to induced colitis |
cecum inflammation |
stomach inflammation |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
enlarged spleen |
spleen hyperplasia |
abnormal T cell differentiation |
abnormal T cell clonal deletion |
increased double-negative T cell number |
decreased double-positive T cell number |
abnormal thrombopoiesis |
increased neutrophil cell number |
abnormal leukocyte cell number |
decreased B-1a cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased activated T cell number |
increased single-positive T cell number |
increased osteoclast cell number |
increased leukocyte cell number |
abnormal osteoclast morphology |
abnormal B cell physiology |
abnormal immunoglobulin level |
decreased IgA level |
increased IgA level |
increased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2a level |
increased IgG2a level |
decreased IgG2b level |
increased IgG2b level |
decreased IgG level |
increased IgG level |
increased IgM level |
decreased immunoglobulin level |
abnormal T cell activation |
abnormal osteoclast physiology |
increased circulating interleukin-6 level |
abnormal bone marrow development |
enlarged mesenteric lymph nodes |
lymph node hyperplasia |
enlarged axillary lymph nodes |
enlarged cervical lymph nodes |
enlarged inguinal lymph nodes |
abnormal dendritic cell antigen presentation |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-4 secretion |
increased interleukin-6 secretion |
increased susceptibility to induced arthritis |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
increased anti-single stranded DNA antibody level |
rheumatoid arthritis |
abnormal inflammatory response |
increased susceptibility to endotoxin shock |
increased inflammatory response |
conjunctivitis |
increased susceptibility to parasitic infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm1Ard/Il6sttm1Ard | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm1Ern/Il6sttm1Ern | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm1Kish/Il6sttm1Kish | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm1Thir/Il6sttm1Thir | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm1Wme/Il6sttm1Wme | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm2Thir/Il6sttm2Thir | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Il6sttm3Thir/Il6sttm3Thir | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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